Both sides have met in the league half a month ago when Bayer Leverkusen beat Union Berlin 3-2.
Bayer Leverkusen have drawn RB Leipzig in their last away league game.
Besides, they got 5 successive wins at home of late, and advanced into next round of the UEFA EL, with hot form.
The AH line is -1 for the home side, which is in favor of Bayer Leverkusen.
So Bayer Leverkusen are expected to win.