Palestino grabbed a big 5-1 win over Cerro Largo in the 2nd round of Copa Libertadores.
On the other hand, Guarani CA eliminated Corinthians Paulista (SP) by an away goal in the 2nd round.
Besides, Guarani CA are good in recent form, winning over FC Nacional Asuncion 2-1 in their last game.
The AH line is -0.25 for the home side with short odds.
With clear home field advantage, the hosts are expected to win.