Both sides got defeated by Bayern in their last game respectively. The difference is that Schalke lost it with a 1-goal deficit, and Hoffenheim suffered a 6-0 loss.
These two teams have been underwhelming lately, and Hoffenheim won their last 2 face-offs. However, the AH line is home team (-0.25), which is in favor of Schalke.
Therefore Schalke should be able to win this home game.